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Different subsets of T cells determine the prognosis of tumors, among which the T cell subsets that are conducive to tumor prognosis and survival mainly include: high levels of CD8 + and CD4 + T cells, high helper T cell (Th)1 to Th2 ratio, and high CD45RO memory T cells (139, 140), while the T cell subsets associated with tumor progression and poor prognosis are predominantly Tregs (141, 142)

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Furthermore, a robust IFN-I response mediated by cGAS activation has been observed in several NDDs during their progression, likely triggered by cellular stress or death